Assay Detail
Functional
CHEMBL710209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to reduce proliferation of human breast adenocarcinoma (MCF-7) cell line by 50% as determined by the MTT method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.32 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353101 | — | — | 1 | 7.10 |
| CHEMBL440012 | — | — | 1 | 6.70 |
| CHEMBL169393 | — | — | 1 | 6.70 |
| CHEMBL436051 | — | — | 1 | 6.70 |
| CHEMBL151423 | — | — | 1 | 6.64 |
| CHEMBL353522 | — | — | 1 | 6.52 |
| CHEMBL355741 | — | — | 1 | 6.52 |
| CHEMBL354952 | — | — | 1 | 6.30 |
| CHEMBL366728 | — | — | 1 | 6.30 |
| CHEMBL168964 | — | — | 1 | 6.30 |
| CHEMBL170164 | — | — | 1 | 6.22 |
| CHEMBL168693 | — | — | 1 | 6.05 |
| CHEMBL168653 | — | — | 1 | 6.00 |
| CHEMBL169305 | — | — | 1 | 6.00 |
| CHEMBL355213 | — | — | 1 | 5.82 |
| CHEMBL354182 | — | — | 1 | 5.80 |
| CHEMBL169995 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353101 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL440012 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL169393 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL436051 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL151423 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL353522 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL355741 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL354952 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL366728 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL168964 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL170164 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL168693 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL168653 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL169305 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL355213 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL354182 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL169995 | — | IC50 | = | 1600.0 | nM | 5.80 |