Assay Detail
Binding
CHEMBL710256
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Ligand-dependent recruitment of steroid receptor co-activator 1 (SRC1) to Liver X receptor-alpha
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.78 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58076 | — | — | 1 | 7.35 |
| CHEMBL62136 | T091317 | — | 1 | 7.22 |
| CHEMBL60393 | — | — | 1 | 7.07 |
| CHEMBL61766 | — | — | 1 | 7.07 |
| CHEMBL434302 | 24(S),25-EPOXYCHOLESTEROL | — | 1 | 7.02 |
| CHEMBL59030 | — | — | 1 | 6.90 |
| CHEMBL61124 | — | — | 1 | 6.72 |
| CHEMBL59359 | — | — | 1 | 6.60 |
| CHEMBL62135 | — | — | 1 | 6.58 |
| CHEMBL61528 | — | — | 1 | 6.58 |
| CHEMBL59082 | — | — | 1 | 6.18 |
| CHEMBL60079 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58076 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL62136 | T091317 | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL60393 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL61766 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL434302 | 24(S),25-EPOXYCHOLESTEROL | EC50 | = | 95.0 | nM | 7.02 |
| CHEMBL59030 | — | EC50 | = | 125.0 | nM | 6.90 |
| CHEMBL61124 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL59359 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL62135 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL61528 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL59082 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL60079 | — | EC50 | = | 860.0 | nM | 6.07 |