Assay Detail
Binding
CHEMBL710257
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Effective concentration in LXR alpha-Gal4 receptor gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.06 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.07 |
| CHEMBL59030 | — | — | 1 | 6.72 |
| CHEMBL58076 | — | — | 1 | 6.37 |
| CHEMBL60393 | — | — | 1 | 6.19 |
| CHEMBL61124 | — | — | 1 | 6.16 |
| CHEMBL59359 | — | — | 1 | 6.04 |
| CHEMBL61766 | — | — | 1 | 6.03 |
| CHEMBL434302 | 24(S),25-EPOXYCHOLESTEROL | — | 1 | 5.52 |
| CHEMBL59082 | — | — | 1 | 5.40 |
| CHEMBL60079 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL59030 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL58076 | — | EC50 | = | 425.0 | nM | 6.37 |
| CHEMBL60393 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL61124 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL59359 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL61766 | — | EC50 | = | 945.0 | nM | 6.03 |
| CHEMBL434302 | 24(S),25-EPOXYCHOLESTEROL | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL59082 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL60079 | — | EC50 | = | 8000.0 | nM | 5.10 |