Assay Detail
Functional
CHEMBL710302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against SO561945 (HIV 1 mutant RT) viral infection of MT-4 cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.06 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL108647 | — | — | 1 | 5.57 |
| CHEMBL108396 | — | — | 1 | 5.24 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.15 |
| CHEMBL431868 | — | — | 1 | 4.71 |
| CHEMBL107180 | — | — | 1 | 4.62 |
| CHEMBL110625 | — | — | 1 | - |
| CHEMBL324237 | — | — | 1 | - |
| CHEMBL108605 | — | — | 1 | - |
| CHEMBL108581 | — | — | 1 | - |
| CHEMBL106661 | — | — | 1 | - |
| CHEMBL31871 | HEPT | — | 1 | - |
| CHEMBL106204 | — | — | 1 | - |
| CHEMBL110328 | — | — | 1 | - |
| CHEMBL108360 | — | — | 1 | - |
| CHEMBL321980 | — | — | 1 | - |
| CHEMBL320056 | — | — | 1 | - |
| CHEMBL320702 | — | — | 1 | - |
| CHEMBL440706 | — | — | 1 | - |
| CHEMBL107562 | — | — | 1 | - |
| CHEMBL316773 | — | — | 1 | - |
| CHEMBL108196 | — | — | 1 | - |
| CHEMBL107606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL108647 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL108396 | — | IC50 | = | 5820.0 | nM | 5.24 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL431868 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL107180 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL110625 | — | IC50 | >= | 275000.0 | nM | - |
| CHEMBL324237 | — | IC50 | = | 188000.0 | nM | - |
| CHEMBL108605 | — | IC50 | >= | 317000.0 | nM | - |
| CHEMBL108581 | — | IC50 | > | 56000.0 | nM | - |
| CHEMBL106661 | — | IC50 | >= | 198000.0 | nM | - |
| CHEMBL31871 | HEPT | IC50 | > | 405000.0 | nM | - |
| CHEMBL106204 | — | IC50 | >= | 58200.0 | nM | - |
| CHEMBL110328 | — | IC50 | >= | 196000.0 | nM | - |
| CHEMBL108360 | — | IC50 | >= | 225000.0 | nM | - |
| CHEMBL321980 | — | IC50 | > | 43100.0 | nM | - |
| CHEMBL320056 | — | IC50 | > | 175000.0 | nM | - |
| CHEMBL320702 | — | IC50 | >= | 5620.0 | nM | - |
| CHEMBL440706 | — | IC50 | > | 178000.0 | nM | - |
| CHEMBL107562 | — | IC50 | > | 179000.0 | nM | - |
| CHEMBL316773 | — | IC50 | > | 270000.0 | nM | - |
| CHEMBL108196 | — | IC50 | >= | 296000.0 | nM | - |
| CHEMBL107606 | — | IC50 | >= | 290000.0 | nM | - |