Assay Detail
Functional
CHEMBL710307
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Inhibitory concentration determined on an HIV infection model mediated by CXCR4
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.75 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373002 | — | — | 1 | 8.10 |
| CHEMBL2372983 | — | — | 1 | 7.99 |
| CHEMBL2372993 | — | — | 1 | 7.91 |
| CHEMBL2372985 | — | — | 1 | 7.71 |
| CHEMBL2372994 | — | — | 1 | 7.64 |
| CHEMBL2373001 | — | — | 1 | 7.63 |
| CHEMBL2372997 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373002 | — | IC50 | = | 8.01 | nM | 8.10 |
| CHEMBL2372983 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL2372993 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL2372985 | — | IC50 | = | 19.3 | nM | 7.71 |
| CHEMBL2372994 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL2373001 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL2372997 | — | IC50 | = | 50.6 | nM | 7.30 |