Assay Detail
Binding
CHEMBL710326
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Inhibition of the Stromelysin enzyme was determined from purified NSO cells.
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NSO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective inhibitors of gelatinase-A 2. carboxylic and phosphonic acid derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.06 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75403 | — | — | 1 | 8.08 |
| CHEMBL76869 | — | — | 2 | 6.56 |
| CHEMBL306177 | — | — | 1 | 6.49 |
| CHEMBL75148 | — | — | 1 | 6.45 |
| CHEMBL307027 | — | — | 1 | 6.45 |
| CHEMBL420376 | — | — | 1 | 6.45 |
| CHEMBL78335 | — | — | 1 | 6.42 |
| CHEMBL307365 | — | — | 1 | 6.33 |
| CHEMBL74977 | — | — | 1 | 6.15 |
| CHEMBL77461 | — | — | 1 | 6.08 |
| CHEMBL307211 | — | — | 1 | 6.02 |
| CHEMBL432346 | — | — | 1 | 6.02 |
| CHEMBL77956 | — | — | 1 | 5.97 |
| CHEMBL309067 | — | — | 1 | 5.96 |
| CHEMBL78047 | — | — | 1 | 5.83 |
| CHEMBL307207 | — | — | 1 | 5.51 |
| CHEMBL306779 | — | — | 1 | 5.08 |
| CHEMBL91055 | — | — | 1 | 4.70 |
| CHEMBL91054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75403 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL76869 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL306177 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL75148 | — | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL307027 | — | Ki | = | 358.0 | nM | 6.45 |
| CHEMBL420376 | — | Ki | = | 358.0 | nM | 6.45 |
| CHEMBL78335 | — | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL307365 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL74977 | — | Ki | = | 701.0 | nM | 6.15 |
| CHEMBL77461 | — | Ki | = | 834.0 | nM | 6.08 |
| CHEMBL307211 | — | Ki | = | 952.0 | nM | 6.02 |
| CHEMBL432346 | — | Ki | = | 952.0 | nM | 6.02 |
| CHEMBL77956 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL309067 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL78047 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL307207 | — | Ki | = | 3120.0 | nM | 5.51 |
| CHEMBL306779 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL91055 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL76869 | — | Ki | = | 21200.0 | nM | 4.67 |
| CHEMBL91054 | — | Ki | > | 10000.0 | nM | - |