Assay Detail
Binding
CHEMBL710329
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Inhibition of human fibroblast stromelysin, matrix metalloprotease-3
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Hydroxamate inhibitors of human gelatinase B (92 kDa)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.84 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116318 | — | — | 1 | 7.96 |
| CHEMBL419301 | — | — | 1 | 7.85 |
| CHEMBL59023 | — | — | 1 | 7.85 |
| CHEMBL87229 | — | — | 1 | 7.82 |
| CHEMBL410259 | — | — | 1 | 7.55 |
| CHEMBL325015 | — | — | 1 | 7.41 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 7.34 |
| CHEMBL11306 | — | — | 1 | 7.05 |
| CHEMBL117720 | — | — | 1 | 5.77 |
| CHEMBL324369 | — | — | 1 | 5.57 |
| CHEMBL117296 | — | — | 1 | 5.46 |
| CHEMBL332891 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116318 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL419301 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL59023 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL87229 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL410259 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL325015 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL19611 | ILOMASTAT | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL11306 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL117720 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL324369 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL117296 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL332891 | — | Ki | = | 40000.0 | nM | 4.40 |