Assay Detail
Binding
CHEMBL710331
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Inhibition of human fibroblast stromelysin, matrix metalloprotease-3
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel indolactam-based inhibitors of matrix metalloproteinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.18 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281795 | — | — | 1 | 8.05 |
| CHEMBL30980 | — | — | 1 | 7.82 |
| CHEMBL30804 | — | — | 1 | 6.09 |
| CHEMBL282146 | — | — | 1 | 5.35 |
| CHEMBL31164 | — | — | 1 | 5.18 |
| CHEMBL30782 | — | — | 1 | 4.60 |
| CHEMBL285112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281795 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL30980 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL30804 | — | Ki | = | 806.0 | nM | 6.09 |
| CHEMBL282146 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL31164 | — | Ki | = | 6575.0 | nM | 5.18 |
| CHEMBL30782 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL285112 | — | Ki | > | 800.0 | nM | - |