Assay Detail
Binding
CHEMBL710334
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Inhibition of human fibroblast stromelysin, matrix metalloprotease-3
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Hydroxamate inhibitors of the matrix metallo-proteinases (MMPs) containing novel P1 heteroatom based modifications
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.15 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86797 | — | — | 1 | 8.22 |
| CHEMBL59023 | — | — | 1 | 7.85 |
| CHEMBL87229 | — | — | 1 | 7.82 |
| CHEMBL410259 | — | — | 1 | 7.55 |
| CHEMBL313483 | — | — | 1 | 7.37 |
| CHEMBL430838 | — | — | 1 | 7.04 |
| CHEMBL85766 | — | — | 1 | 6.44 |
| CHEMBL87046 | — | — | 1 | 6.37 |
| CHEMBL86468 | — | — | 1 | 5.66 |
| CHEMBL85933 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86797 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL59023 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL87229 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL410259 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL313483 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL430838 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL85766 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL87046 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL86468 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL85933 | — | Ki | > | 10000.0 | nM | - |