Assay Detail
Binding
CHEMBL710481
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Inhibition of matrilysin, matrix metalloprotease-7
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2-P3 amide bond isostere
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.21 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288896 | — | — | 1 | 9.64 |
| CHEMBL40351 | — | — | 1 | 9.00 |
| CHEMBL40237 | — | — | 1 | 9.00 |
| CHEMBL296874 | — | — | 1 | 8.70 |
| CHEMBL41497 | — | — | 1 | 8.51 |
| CHEMBL288649 | — | — | 1 | 8.00 |
| CHEMBL289513 | — | — | 1 | 8.00 |
| CHEMBL40589 | — | — | 1 | 8.00 |
| CHEMBL43403 | — | — | 1 | 7.75 |
| CHEMBL42311 | — | — | 1 | 7.48 |
| CHEMBL298033 | — | — | 1 | 7.30 |
| CHEMBL289842 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288896 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL40351 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL40237 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL296874 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL41497 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL288649 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL289513 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL40589 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL43403 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL42311 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL298033 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL289842 | — | IC50 | = | 70.0 | nM | 7.16 |