Assay Detail
Binding
CHEMBL710497
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In vitro inhibitory activity on rat brain by monoamine oxidase A (MAO-A)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.16 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.92 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 6.10 |
| CHEMBL16988 | — | — | 1 | 5.70 |
| CHEMBL277140 | — | — | 1 | 5.58 |
| CHEMBL16642 | — | — | 1 | 5.57 |
| CHEMBL16569 | — | — | 1 | 5.48 |
| CHEMBL277760 | — | — | 1 | 5.47 |
| CHEMBL16278 | — | — | 1 | 5.32 |
| CHEMBL16477 | — | — | 1 | 5.13 |
| CHEMBL430099 | — | — | 1 | 5.09 |
| CHEMBL17081 | — | — | 1 | 5.00 |
| CHEMBL16956 | — | — | 1 | 4.96 |
| CHEMBL16718 | — | — | 1 | 4.96 |
| CHEMBL17079 | — | — | 1 | 4.92 |
| CHEMBL17078 | — | — | 1 | 4.89 |
| CHEMBL416167 | — | — | 1 | 4.85 |
| CHEMBL16660 | — | — | 1 | 4.80 |
| CHEMBL16771 | — | — | 1 | 4.72 |
| CHEMBL17093 | — | — | 1 | 4.70 |
| CHEMBL16541 | — | — | 1 | 4.60 |
| CHEMBL16697 | — | — | 1 | 4.60 |
| CHEMBL16648 | — | — | 1 | 4.50 |
| CHEMBL279361 | — | — | 1 | 4.40 |
| CHEMBL16752 | — | — | 1 | 4.35 |
| CHEMBL16530 | — | — | 1 | 4.35 |
| CHEMBL16825 | — | — | 1 | - |
| CHEMBL277139 | — | — | 1 | - |
| CHEMBL16623 | — | — | 1 | - |
| CHEMBL16781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL972 | SELEGILINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL16988 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL277140 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL16642 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL16569 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL277760 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL16278 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL16477 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL430099 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL17081 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL16956 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL16718 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL17079 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL17078 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL416167 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL16660 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL16771 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL17093 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL16541 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL16697 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL16648 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL279361 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL16752 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL16530 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL16825 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL277139 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL16623 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL16781 | — | IC50 | = | 140000.0 | nM | - |