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Assay Detail

CHEMBL710550

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Binding
Inhibition of MMP-2.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

72 kDa type IV collagenase (CHEMBL333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of matrix metalloproteinases by P1 substituted N-carboxyalkyl dipeptides
Chapman KT, Wales J, Sahoo SP, Niedzwiecki LM, Izquierdo-Martin M, Chang BC, Harrison RK, Stein RL, Hagmann WK
Bioorg Med Chem Lett (1996) 6 : 329 -332
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.64 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL111017 1 7.70
CHEMBL113322 1 7.22
CHEMBL331364 1 7.16
CHEMBL112180 1 7.07
CHEMBL112147 1 6.96
CHEMBL323917 1 6.92
CHEMBL326795 1 6.92
CHEMBL8494 L-696418 1 6.70
CHEMBL112508 1 6.46
CHEMBL112803 1 6.24
CHEMBL325007 1 6.11
CHEMBL423686 1 5.96
CHEMBL432642 1 5.96
CHEMBL321006 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL111017 Ki = 20.0 nM 7.70
CHEMBL113322 Ki = 60.0 nM 7.22
CHEMBL331364 Ki = 70.0 nM 7.16
CHEMBL112180 Ki = 86.0 nM 7.07
CHEMBL112147 Ki = 110.0 nM 6.96
CHEMBL323917 Ki = 120.0 nM 6.92
CHEMBL326795 Ki = 120.0 nM 6.92
CHEMBL8494 L-696418 Ki = 200.0 nM 6.70
CHEMBL112508 Ki = 350.0 nM 6.46
CHEMBL112803 Ki = 570.0 nM 6.24
CHEMBL325007 Ki = 770.0 nM 6.11
CHEMBL423686 Ki = 1100.0 nM 5.96
CHEMBL432642 Ki = 1100.0 nM 5.96
CHEMBL321006 Ki = 2300.0 nM 5.64