Assay Detail
Binding
CHEMBL710559
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Inhibition of human neutrophil gelatinase, matrix metalloprotease-2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel indolactam-based inhibitors of matrix metalloproteinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.87 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285418 | — | — | 1 | 9.52 |
| CHEMBL30980 | — | — | 1 | 8.70 |
| CHEMBL282146 | — | — | 1 | 6.94 |
| CHEMBL286904 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285418 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL30980 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL282146 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL286904 | — | Ki | = | 472.0 | nM | 6.33 |