Assay Detail
Binding
CHEMBL710562
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Inhibition of matrix metalloprotease-2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.28 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47468 | — | — | 1 | 8.64 |
| CHEMBL47414 | — | — | 1 | 8.39 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47468 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL47414 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 15.0 | nM | 7.82 |