Assay Detail
Binding
CHEMBL710567
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Inhibition of fibroblast stromelysin (MMP-3)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.88 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418291 | — | — | 1 | 8.82 |
| CHEMBL304243 | — | — | 1 | 8.74 |
| CHEMBL65159 | — | — | 1 | 8.59 |
| CHEMBL418292 | — | — | 1 | 8.41 |
| CHEMBL66134 | — | — | 1 | 8.38 |
| CHEMBL62007 | — | — | 1 | 8.21 |
| CHEMBL66532 | — | — | 1 | 8.16 |
| CHEMBL45631 | — | — | 1 | 8.11 |
| CHEMBL64013 | — | — | 1 | 8.04 |
| CHEMBL293003 | — | — | 1 | 7.92 |
| CHEMBL303298 | — | — | 1 | 7.92 |
| CHEMBL304221 | — | — | 1 | 7.12 |
| CHEMBL302227 | — | — | 1 | 6.24 |
| CHEMBL433250 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418291 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL304243 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL65159 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL418292 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL66134 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL62007 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL66532 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL45631 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL64013 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL293003 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL303298 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL304221 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL302227 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL433250 | — | IC50 | = | 2100.0 | nM | 5.68 |