Assay Detail
Binding
CHEMBL710598
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In vitro inhibitory activity against matrix metalloprotease 2 isolated from human HT1080 fibrosarcoma cells induced with TNF
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.34 | 9.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321180 | — | — | 1 | 9.42 |
| CHEMBL432397 | — | — | 1 | 9.22 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 9.07 |
| CHEMBL320782 | — | — | 1 | 9.00 |
| CHEMBL324664 | — | — | 1 | 8.96 |
| CHEMBL432991 | — | — | 1 | 8.96 |
| CHEMBL111798 | — | — | 1 | 8.80 |
| CHEMBL432079 | — | — | 1 | 8.74 |
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 8.68 |
| CHEMBL62007 | — | — | 1 | 8.64 |
| CHEMBL411851 | — | — | 1 | 8.57 |
| CHEMBL111104 | — | — | 1 | 8.47 |
| CHEMBL111736 | — | — | 1 | 8.41 |
| CHEMBL325940 | — | — | 1 | 8.29 |
| CHEMBL418292 | — | — | 1 | 8.25 |
| CHEMBL324874 | — | — | 1 | 8.21 |
| CHEMBL419011 | — | — | 1 | 8.19 |
| CHEMBL320045 | — | — | 1 | 8.14 |
| CHEMBL430524 | — | — | 1 | 8.14 |
| CHEMBL109596 | — | — | 1 | 8.07 |
| CHEMBL109239 | — | — | 1 | 8.07 |
| CHEMBL325552 | — | — | 1 | 8.02 |
| CHEMBL110527 | — | — | 1 | 7.66 |
| CHEMBL110696 | — | — | 1 | 7.64 |
| CHEMBL109706 | — | — | 1 | 7.48 |
| CHEMBL321602 | — | — | 1 | 7.04 |
| CHEMBL109246 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321180 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL432397 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL320782 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL324664 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL432991 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL111798 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL432079 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL279786 | BATIMASTAT | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL62007 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL411851 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL111104 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL111736 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL325940 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL418292 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL324874 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL419011 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL320045 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL430524 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL109596 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL109239 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL325552 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL110527 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL110696 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL109706 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL321602 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL109246 | — | IC50 | = | 110.0 | nM | 6.96 |