Assay Detail
Functional
CHEMBL710650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required to reduce cell number to 50% of control cultures in LL(Lewis lung carcinoma cell line)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lewis lung carcinoma |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.01 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283677 | — | — | 1 | 9.52 |
| CHEMBL30628 | — | — | 1 | 9.47 |
| CHEMBL286429 | — | — | 1 | 9.34 |
| CHEMBL285349 | — | — | 1 | 8.92 |
| CHEMBL30424 | — | — | 1 | 8.55 |
| CHEMBL31879 | — | — | 1 | 8.41 |
| CHEMBL29602 | — | — | 1 | 8.25 |
| CHEMBL30912 | — | — | 1 | 8.00 |
| CHEMBL31400 | ELINAFIDE | 2.0 | 1 | 7.96 |
| CHEMBL32741 | — | — | 1 | 7.92 |
| CHEMBL31790 | — | — | 1 | 7.70 |
| CHEMBL283010 | — | — | 1 | 7.51 |
| CHEMBL30843 | — | — | 1 | 7.46 |
| CHEMBL286942 | — | — | 1 | 7.41 |
| CHEMBL31769 | — | — | 1 | 7.32 |
| CHEMBL285322 | — | — | 1 | 6.95 |
| CHEMBL29944 | — | — | 1 | 6.92 |
| CHEMBL287582 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283677 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL30628 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL286429 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL285349 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL30424 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL31879 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL29602 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL30912 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL31400 | ELINAFIDE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL32741 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL31790 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL283010 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL30843 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL286942 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL31769 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL285322 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL29944 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL287582 | — | IC50 | = | 290.0 | nM | 6.54 |