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Assay Detail

CHEMBL710653

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Functional
Inhibitory activity against Lewis lung carcinoma cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type Lewis lung carcinoma
Confidence 1 — Organism
Curated By Expert

Target

Lewis lung carcinoma cell line (CHEMBL614088)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives.
Bu X, Deady LW, Finlay GJ, Baguley BC, Denny WA.
J Med Chem (2001) 44 : 2004 -2014
PubMed 11384245 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.53 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL43 AMSACRINE 4.0 1 7.92
CHEMBL65 CAMPTOTHECIN -1.0 1 7.48
CHEMBL64071 1 7.46
CHEMBL60129 1 7.01
CHEMBL276261 1 7.00
CHEMBL64378 1 6.89
CHEMBL433253 1 6.70
CHEMBL303559 1 6.33
CHEMBL60794 1 6.32
CHEMBL61526 1 6.28
CHEMBL292079 1 6.14
CHEMBL59664 1 6.08
CHEMBL61064 1 6.05
CHEMBL294064 1 5.99
CHEMBL62324 1 5.97
CHEMBL292038 1 5.75
CHEMBL293209 1 5.61

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL43 AMSACRINE IC50 = 12.0 nM 7.92
CHEMBL65 CAMPTOTHECIN IC50 = 33.0 nM 7.48
CHEMBL64071 IC50 = 35.0 nM 7.46
CHEMBL60129 IC50 = 98.0 nM 7.01
CHEMBL276261 IC50 = 101.0 nM 7.00
CHEMBL64378 IC50 = 128.0 nM 6.89
CHEMBL433253 IC50 = 200.0 nM 6.70
CHEMBL303559 IC50 = 472.0 nM 6.33
CHEMBL60794 IC50 = 483.0 nM 6.32
CHEMBL61526 IC50 = 525.0 nM 6.28
CHEMBL292079 IC50 = 717.0 nM 6.14
CHEMBL59664 IC50 = 830.0 nM 6.08
CHEMBL61064 IC50 = 887.0 nM 6.05
CHEMBL294064 IC50 = 1030.0 nM 5.99
CHEMBL62324 IC50 = 1080.0 nM 5.97
CHEMBL292038 IC50 = 1790.0 nM 5.75
CHEMBL293209 IC50 = 2480.0 nM 5.61