Assay Detail
Functional
CHEMBL710654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration to reduce cell number to 50% in a panel of cultured, murine Lewis lung carcinoma (LL) cells.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lewis lung carcinoma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.62 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL349474 | — | — | 1 | 8.62 |
| CHEMBL433703 | — | — | 1 | 8.39 |
| CHEMBL162739 | — | — | 1 | 8.23 |
| CHEMBL162885 | — | — | 1 | 8.19 |
| CHEMBL163525 | — | — | 1 | 7.96 |
| CHEMBL355827 | — | — | 1 | 7.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.66 |
| CHEMBL162112 | — | — | 1 | 7.64 |
| CHEMBL162987 | — | — | 1 | 7.60 |
| CHEMBL351244 | — | — | 1 | 7.39 |
| CHEMBL163577 | — | — | 1 | 7.27 |
| CHEMBL353127 | — | — | 1 | 7.18 |
| CHEMBL163072 | — | — | 1 | 7.05 |
| CHEMBL164407 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL349474 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL433703 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL162739 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL162885 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL163525 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL355827 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL162112 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL162987 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL351244 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL163577 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL353127 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL163072 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL164407 | — | IC50 | = | 1850.0 | nM | 5.73 |