Assay Detail
Functional
CHEMBL710692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of arachidonic acid(AA) release from CHO cells in Monkey
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cercopithecidae |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.56 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435167 | — | — | 1 | 8.15 |
| CHEMBL22055 | SUFUGOLIX | 2.0 | 1 | 8.00 |
| CHEMBL21126 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435167 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL22055 | SUFUGOLIX | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL21126 | — | IC50 | = | 300.0 | nM | 6.52 |