Assay Detail
Binding
CHEMBL710870
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Inhibitory activity against Lysophosphatidic acid acyltransferase-beta expressed in Sf9 insect cell membranes
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (CHEMBL4772) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.64 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75167 | — | — | 1 | 8.00 |
| CHEMBL310136 | — | — | 1 | 7.80 |
| CHEMBL308945 | — | — | 1 | 7.77 |
| CHEMBL77883 | — | — | 1 | 7.77 |
| CHEMBL74548 | — | — | 1 | 7.75 |
| CHEMBL307716 | — | — | 1 | 7.70 |
| CHEMBL311379 | — | — | 1 | 7.66 |
| CHEMBL74492 | — | — | 1 | 7.62 |
| CHEMBL74708 | — | — | 1 | 7.55 |
| CHEMBL424605 | — | — | 1 | 7.55 |
| CHEMBL74549 | — | — | 1 | 7.51 |
| CHEMBL73376 | — | — | 1 | 7.47 |
| CHEMBL72618 | — | — | 1 | 7.47 |
| CHEMBL306107 | — | — | 1 | 7.27 |
| CHEMBL75522 | — | — | 1 | 7.12 |
| CHEMBL76274 | — | — | 1 | 7.10 |
| CHEMBL72992 | — | — | 1 | 7.08 |
| CHEMBL73574 | — | — | 1 | 7.06 |
| CHEMBL74932 | — | — | 1 | 7.04 |
| CHEMBL309911 | — | — | 1 | 6.92 |
| CHEMBL422414 | — | — | 1 | 6.85 |
| CHEMBL73947 | — | — | 1 | 6.82 |
| CHEMBL75714 | — | — | 1 | 6.68 |
| CHEMBL75132 | — | — | 1 | 6.64 |
| CHEMBL305915 | — | — | 1 | 6.40 |
| CHEMBL308275 | — | — | 1 | 6.35 |
| CHEMBL77790 | — | — | 1 | 6.24 |
| CHEMBL305688 | — | — | 1 | 6.21 |
| CHEMBL73912 | — | — | 1 | 6.19 |
| CHEMBL74931 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75167 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL310136 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL77883 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL308945 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL74548 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL307716 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL311379 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL74492 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL74708 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL424605 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL74549 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL72618 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL73376 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL306107 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL75522 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL76274 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL72992 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL73574 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL74932 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL309911 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL422414 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL73947 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL75714 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL75132 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL305915 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL308275 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL77790 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL305688 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL73912 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL74931 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL308100 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL75170 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL75467 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL75791 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL72202 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL74188 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL77940 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL312087 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL75561 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL309753 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL75889 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL75203 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL451233 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL75551 | — | IC50 | > | 5000.0 | nM | - |