Assay Detail
Functional
CHEMBL710938
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In vitro antiviral activity against Human cytomegalovirus (HCMV)strain AD169 in MRC-5 lung fibroblasts using a DNA-hybridization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
An enantiospecific synthesis of the human cytomegalovirus antiviral agent [(R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.49 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413540 | — | — | 1 | 5.77 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.77 |
| CHEMBL282358 | — | — | 1 | 5.25 |
| CHEMBL28822 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413540 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL282358 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL28822 | — | IC50 | = | 6800.0 | nM | 5.17 |