Assay Detail
Binding
CHEMBL710978
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Inhibition of matrix metalloprotease-13
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.04 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47728 | — | — | 1 | 8.52 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.46 |
| CHEMBL47414 | — | — | 1 | 8.42 |
| CHEMBL47468 | — | — | 1 | 8.35 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.92 |
| CHEMBL296911 | — | — | 1 | 7.92 |
| CHEMBL45162 | — | — | 1 | 7.70 |
| CHEMBL45357 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47728 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL47414 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL47468 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL296911 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL45162 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL45357 | — | IC50 | = | 96.0 | nM | 7.02 |