Assay Detail
Binding
CHEMBL710982
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In vitro inhibition of Matrix metalloprotease-2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.87 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415872 | — | — | 1 | 5.47 |
| CHEMBL434204 | — | — | 1 | 5.28 |
| CHEMBL288510 | — | — | 1 | 5.16 |
| CHEMBL41102 | — | — | 1 | 5.11 |
| CHEMBL41100 | — | — | 1 | 5.09 |
| CHEMBL288592 | — | — | 1 | 4.92 |
| CHEMBL288701 | — | — | 1 | 4.60 |
| CHEMBL38717 | — | — | 1 | 4.43 |
| CHEMBL290457 | — | — | 1 | 4.35 |
| CHEMBL288067 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415872 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL434204 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL288510 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL41102 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL41100 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL288592 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL288701 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL38717 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL290457 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL288067 | — | IC50 | = | 58000.0 | nM | 4.24 |