Assay Detail
Binding
CHEMBL711196
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Inhibition of Strom-1 MMP-3
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.34 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100100 | — | — | 1 | 8.15 |
| CHEMBL329313 | — | — | 1 | 7.52 |
| CHEMBL97936 | — | — | 1 | 7.30 |
| CHEMBL328162 | — | — | 1 | 7.22 |
| CHEMBL316954 | — | — | 1 | 7.22 |
| CHEMBL329298 | — | — | 1 | 7.00 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 6.70 |
| CHEMBL98044 | — | — | 1 | 6.70 |
| CHEMBL99981 | — | — | 1 | 6.52 |
| CHEMBL99189 | — | — | 1 | 6.40 |
| CHEMBL99148 | — | — | 1 | 6.40 |
| CHEMBL318190 | — | — | 1 | 6.40 |
| CHEMBL98017 | — | — | 1 | 6.10 |
| CHEMBL318716 | — | — | 1 | 6.10 |
| CHEMBL95614 | — | — | 1 | 5.70 |
| CHEMBL97382 | — | — | 1 | 5.70 |
| CHEMBL98917 | — | — | 1 | 5.40 |
| CHEMBL328381 | — | — | 1 | 5.30 |
| CHEMBL329287 | — | — | 1 | 5.22 |
| CHEMBL318455 | — | — | 1 | 5.16 |
| CHEMBL318023 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100100 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL329313 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL97936 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL328162 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL316954 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL329298 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL98044 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL99981 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL99189 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL99148 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL318190 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL98017 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL318716 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL95614 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL97382 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL98917 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL328381 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL329287 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL318455 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL318023 | — | IC50 | = | 10000.0 | nM | 5.00 |