Assay Detail
Functional
CHEMBL711287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of MTX-resistant R2(Bos) sublines.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.65 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430872 | — | — | 1 | 6.37 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.80 |
| CHEMBL1237205 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430872 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL34259 | METHOTREXATE | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1237205 | — | EC50 | = | 17000.0 | nM | 4.77 |