Assay Detail
Functional
CHEMBL711291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of MTX-resistant R30dm sublines.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Effect of C9-methyl substitution and C8-C9 conformational restriction on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.37 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 7.85 |
| CHEMBL430872 | — | — | 1 | 6.66 |
| CHEMBL323565 | — | — | 1 | 6.37 |
| CHEMBL106628 | — | — | 1 | 6.18 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | — | 1 | 5.99 |
| CHEMBL1237205 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL430872 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL323565 | — | EC50 | = | 425.0 | nM | 6.37 |
| CHEMBL106628 | — | EC50 | = | 663.0 | nM | 6.18 |
| CHEMBL104829 | FURO[2,3D]PYRIMIDINE ANTIFOLATE | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1237205 | — | EC50 | = | 6400.0 | nM | 5.19 |