Assay Detail
Binding
CHEMBL711315
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Inhibition of Matrix metalloprotease-8
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Heterocycle-based MMP inhibitors with P2' substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.26 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7108 | — | — | 1 | 8.82 |
| CHEMBL415482 | — | — | 1 | 8.82 |
| CHEMBL427616 | — | — | 1 | 8.74 |
| CHEMBL269019 | — | — | 1 | 8.55 |
| CHEMBL267939 | — | — | 1 | 8.48 |
| CHEMBL7756 | — | — | 1 | 8.43 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.36 |
| CHEMBL268377 | — | — | 1 | 8.20 |
| CHEMBL7390 | — | — | 1 | 8.19 |
| CHEMBL268114 | — | — | 1 | 8.18 |
| CHEMBL6973 | — | — | 1 | 7.33 |
| CHEMBL266292 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7108 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL415482 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL427616 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL269019 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL267939 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL7756 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL268377 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL7390 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL268114 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL6973 | — | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL266292 | — | IC50 | = | 102.0 | nM | 6.99 |