Assay Detail
Functional
CHEMBL711403
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Anti-HIV activity based on inhibition of HIV-1 induced cytopathogenicity in MT-2 cells.
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.46 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49002 | — | — | 1 | 8.02 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 7.77 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.57 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.44 |
| CHEMBL299578 | — | — | 1 | 7.18 |
| CHEMBL50945 | — | — | 1 | 6.80 |
| CHEMBL48781 | — | — | 2 | - |
| CHEMBL49239 | — | — | 2 | - |
| CHEMBL298962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49002 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL299578 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL50945 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL48781 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL49239 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL49239 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL48781 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL298962 | — | IC50 | > | 1000.0 | nM | - |