Assay Detail
Functional
CHEMBL711488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against rhinoviral-18 serotype in a plaque inhibition assay using monolayers of M-HeLa cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human rhinovirus sp. |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.12 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283830 | — | — | 1 | 5.75 |
| CHEMBL301081 | — | — | 1 | 5.21 |
| CHEMBL51178 | — | — | 1 | 5.11 |
| CHEMBL300881 | — | — | 1 | 5.10 |
| CHEMBL299013 | — | — | 1 | 5.09 |
| CHEMBL49403 | — | — | 1 | 5.06 |
| CHEMBL49668 | — | — | 1 | 5.00 |
| CHEMBL48702 | — | — | 1 | 4.89 |
| CHEMBL51383 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283830 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL301081 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL51178 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL300881 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL299013 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL49403 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL49668 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL48702 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL51383 | — | IC50 | = | 14000.0 | nM | 4.85 |