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Assay Detail

CHEMBL711491

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Functional
Antiviral activity against rhinoviral-1B serotype in a plaque inhibition assay using monolayers of M-HeLa cells
ChEMBL ↗
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus sp.
Cell Type HeLa
Confidence 1 — Organism
Curated By Expert

Target

Human rhinovirus sp. (CHEMBL612470) ↗
Type ORGANISM
Organism Human rhinovirus sp.

Publication

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines.
Kelley JL, Linn JA, Selway JW.
J Med Chem (1989) 32 : 1757 -1763
PubMed 2547069 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 61 6.43 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL301387 — — 1 7.52
CHEMBL300881 — — 1 7.52
CHEMBL48926 — — 1 7.52
CHEMBL283830 — — 1 7.52
CHEMBL299959 — — 1 7.40
CHEMBL49821 — — 1 7.30
CHEMBL301101 — — 1 7.22
CHEMBL48312 — — 1 7.16
CHEMBL51194 — — 1 7.16
CHEMBL52005 — — 1 7.00
CHEMBL301081 — — 1 6.96
CHEMBL51721 — — 1 6.96
CHEMBL49668 — — 1 6.92
CHEMBL48774 — — 1 6.92
CHEMBL299013 — — 1 6.92
CHEMBL302487 — — 1 6.92
CHEMBL49066 — — 1 6.89
CHEMBL49161 — — 1 6.89
CHEMBL299201 — — 1 6.82
CHEMBL51846 — — 1 6.77
CHEMBL51383 — — 1 6.77
CHEMBL50299 — — 1 6.77
CHEMBL48748 — — 1 6.75
CHEMBL48702 — — 1 6.70
CHEMBL298184 — — 1 6.70
CHEMBL301099 — — 1 6.70
CHEMBL51845 — — 1 6.70
CHEMBL51341 — — 1 6.60
CHEMBL301581 — — 1 6.54
CHEMBL51178 — — 1 6.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL301387 — IC50 = 30.0 nM 7.52
CHEMBL283830 — IC50 = 30.0 nM 7.52
CHEMBL48926 — IC50 = 30.0 nM 7.52
CHEMBL300881 — IC50 = 30.0 nM 7.52
CHEMBL299959 — IC50 = 40.0 nM 7.40
CHEMBL49821 — IC50 = 50.0 nM 7.30
CHEMBL301101 — IC50 = 60.0 nM 7.22
CHEMBL48312 — IC50 = 70.0 nM 7.16
CHEMBL51194 — IC50 = 70.0 nM 7.16
CHEMBL52005 — IC50 = 100.0 nM 7.00
CHEMBL301081 — IC50 = 110.0 nM 6.96
CHEMBL51721 — IC50 = 110.0 nM 6.96
CHEMBL48774 — IC50 = 120.0 nM 6.92
CHEMBL49668 — IC50 = 120.0 nM 6.92
CHEMBL299013 — IC50 = 120.0 nM 6.92
CHEMBL302487 — IC50 = 120.0 nM 6.92
CHEMBL49066 — IC50 = 130.0 nM 6.89
CHEMBL49161 — IC50 = 130.0 nM 6.89
CHEMBL299201 — IC50 = 150.0 nM 6.82
CHEMBL51846 — IC50 = 170.0 nM 6.77
CHEMBL51383 — IC50 = 170.0 nM 6.77
CHEMBL50299 — IC50 = 170.0 nM 6.77
CHEMBL48748 — IC50 = 180.0 nM 6.75
CHEMBL51845 — IC50 = 200.0 nM 6.70
CHEMBL301099 — IC50 = 200.0 nM 6.70
CHEMBL48702 — IC50 = 200.0 nM 6.70
CHEMBL298184 — IC50 = 200.0 nM 6.70
CHEMBL51341 — IC50 = 250.0 nM 6.60
CHEMBL301581 — IC50 = 290.0 nM 6.54
CHEMBL51178 — IC50 = 290.0 nM 6.54
CHEMBL50896 — IC50 = 300.0 nM 6.52
CHEMBL297874 — IC50 = 300.0 nM 6.52
CHEMBL50918 — IC50 = 370.0 nM 6.43
CHEMBL46442 — IC50 = 470.0 nM 6.33
CHEMBL299993 — IC50 = 500.0 nM 6.30
CHEMBL51894 — IC50 = 530.0 nM 6.28
CHEMBL49403 — IC50 = 560.0 nM 6.25
CHEMBL48535 — IC50 = 680.0 nM 6.17
CHEMBL417536 — IC50 = 740.0 nM 6.13
CHEMBL46047 — IC50 = 780.0 nM 6.11
CHEMBL48569 — IC50 = 950.0 nM 6.02
CHEMBL49452 — IC50 = 1000.0 nM 6.00
CHEMBL51525 — IC50 = 1100.0 nM 5.96
CHEMBL297924 — IC50 = 1700.0 nM 5.77
CHEMBL297515 — IC50 = 2100.0 nM 5.68
CHEMBL50240 — IC50 = 2100.0 nM 5.68
CHEMBL51878 — IC50 = 2600.0 nM 5.58
CHEMBL48288 — IC50 = 4400.0 nM 5.36
CHEMBL50963 — IC50 = 4600.0 nM 5.34
CHEMBL50220 — IC50 = 4600.0 nM 5.34