Assay Detail
Functional
CHEMBL711532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxic activity against uterine sarcoma (MES-SA) cells assayed by inhibition of [3H]-labeled thymidine incorporation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.52 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 10.70 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 10.40 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.04 |
| CHEMBL138287 | — | — | 1 | 5.68 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.27 |
| CHEMBL138636 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL138287 | — | IC50 | = | 2109.0 | nM | 5.68 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL138636 | — | IC50 | = | 9594.0 | nM | 5.02 |