Assay Detail
Binding
CHEMBL711564
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Inhibition of Matrix metalloprotease-7 Matrilysin
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure-activity study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.58 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87786 | — | — | 1 | 8.40 |
| CHEMBL89057 | — | — | 1 | 6.93 |
| CHEMBL85744 | — | — | 1 | 6.68 |
| CHEMBL313896 | — | — | 1 | 6.43 |
| CHEMBL313472 | — | — | 1 | 6.22 |
| CHEMBL313386 | — | — | 1 | 5.75 |
| CHEMBL88187 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87786 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL89057 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL85744 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL313896 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL313472 | — | Ki | = | 605.0 | nM | 6.22 |
| CHEMBL313386 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL88187 | — | Ki | = | 2100.0 | nM | 5.68 |