Assay Detail
Binding
CHEMBL711569
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Inhibition of Matrix metalloprotease-7
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel indolactam-based inhibitors of matrix metalloproteinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.00 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281795 | — | — | 1 | 8.52 |
| CHEMBL285418 | — | — | 1 | 8.30 |
| CHEMBL30980 | — | — | 1 | 7.75 |
| CHEMBL30804 | — | — | 1 | 7.11 |
| CHEMBL285112 | — | — | 1 | 6.94 |
| CHEMBL282146 | — | — | 1 | 6.07 |
| CHEMBL31164 | — | — | 1 | 5.85 |
| CHEMBL30782 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281795 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL285418 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL30980 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL30804 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL285112 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL282146 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL31164 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL30782 | — | Ki | = | 3225.0 | nM | 5.49 |