Assay Detail
Functional
CHEMBL711574
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In vitro inhibitory activity on MRC5 fibroblast tissue cultures inoculated with virulent RH strain of Toxoplasma gondii
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of new fluoroquinolones and evaluation of their in vitro activity on Toxoplasma gondii and Plasmodium spp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.06 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428 | TROVAFLOXACIN | 4.0 | 1 | 6.02 |
| CHEMBL95155 | TROVAFLOXACIN4 | — | 1 | 5.78 |
| CHEMBL93307 | — | — | 1 | 5.68 |
| CHEMBL32 | MOXIFLOXACIN | 4.0 | 1 | 4.96 |
| CHEMBL31 | GATIFLOXACIN | 4.0 | 1 | 4.90 |
| CHEMBL96896 | — | — | 1 | 4.50 |
| CHEMBL315647 | — | — | 1 | 4.43 |
| CHEMBL314302 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428 | TROVAFLOXACIN | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL95155 | TROVAFLOXACIN4 | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL93307 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL32 | MOXIFLOXACIN | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL31 | GATIFLOXACIN | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL96896 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL315647 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL314302 | — | IC50 | = | 66000.0 | nM | 4.18 |