Assay Detail
Functional
CHEMBL711604
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Compound was tested for anti-rhinovirus type 1B activity in a plaque inhibition assay using monolayers of M-HeLa cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 2-substituted-6-(dimethylamino)-9-(4-methylbenzyl)-9H-purines with antirhinovirus activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.89 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283830 | — | — | 1 | 7.52 |
| CHEMBL416937 | — | — | 1 | 7.10 |
| CHEMBL305661 | — | — | 1 | 6.47 |
| CHEMBL306857 | — | — | 1 | 6.47 |
| CHEMBL72589 | — | — | 1 | 6.10 |
| CHEMBL72360 | — | — | 1 | 5.96 |
| CHEMBL538916 | — | — | 1 | 5.64 |
| CHEMBL431375 | — | — | 1 | 5.33 |
| CHEMBL403464 | — | — | 1 | 5.07 |
| CHEMBL71076 | — | — | 1 | 4.60 |
| CHEMBL70888 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283830 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL416937 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL305661 | — | IC50 | = | 338.84 | nM | 6.47 |
| CHEMBL306857 | — | IC50 | = | 338.84 | nM | 6.47 |
| CHEMBL72589 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL72360 | — | IC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL538916 | — | IC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL431375 | — | IC50 | = | 4677.35 | nM | 5.33 |
| CHEMBL403464 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL71076 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL70888 | — | IC50 | = | 30902.95 | nM | 4.51 |