Assay Detail
Functional
CHEMBL711615
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In vitro cytotoxicity against human cancerous cells (MCF-7) was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.00 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64318 | — | — | 1 | 7.21 |
| CHEMBL416673 | — | — | 1 | 7.09 |
| CHEMBL293834 | — | — | 1 | 7.01 |
| CHEMBL61102 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64318 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL416673 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL293834 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL61102 | — | IC50 | = | 200.0 | nM | 6.70 |