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Assay Detail

CHEMBL711626

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Functional
Inhibitory activity against MAC13 cell lines
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type MAC13
Confidence 1 — Organism
Curated By Intermediate

Target

MAC13 (CHEMBL614042)
Type CELL-LINE
Organism Mus musculus

Publication

Effect of catechol derivatives on cell growth and lipoxygenase activity.
Simpson J, Forrester R, Tisdale MJ, Billington DC, Rathbone DL.
Bioorg Med Chem Lett (2003) 13 : 2435 -2439
PubMed 12852938 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 5 5.81 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL81583 1 6.48
CHEMBL312805 1 6.05
CHEMBL420775 1 5.52
CHEMBL82479 1 5.20
CHEMBL309694 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL81583 IC50 = 330.0 nM 6.48
CHEMBL312805 IC50 = 900.0 nM 6.05
CHEMBL420775 IC50 = 3000.0 nM 5.52
CHEMBL82479 IC50 = 6300.0 nM 5.20
CHEMBL309694 IC50 > 50000.0 nM -