Assay Detail
Functional
CHEMBL711672
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Anti-proliferative activity against human tumor cell line MDA-435
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Trifluoromethyl ketones as inhibitors of histone deacetylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.89 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116702 | — | — | 1 | 5.47 |
| CHEMBL323652 | — | — | 1 | 5.01 |
| CHEMBL323647 | — | — | 1 | 4.92 |
| CHEMBL331158 | — | — | 1 | 4.82 |
| CHEMBL113537 | — | — | 1 | 4.82 |
| CHEMBL115011 | — | — | 1 | 4.64 |
| CHEMBL112148 | — | — | 1 | 4.52 |
| CHEMBL117610 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116702 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL323652 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL323647 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL331158 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL113537 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL115011 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL112148 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL117610 | — | IC50 | > | 50000.0 | nM | - |