Assay Detail
Functional
CHEMBL711680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on reversal of DOX accumulation in MDA-435/LCC6 (Pgp-negative) cells.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.51 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL131172 | — | — | 1 | 6.16 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.16 |
| CHEMBL419965 | — | — | 1 | 6.05 |
| CHEMBL338904 | — | — | 1 | 6.00 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.39 |
| CHEMBL129251 | — | — | 1 | 4.43 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL131172 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL419965 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL338904 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL129251 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 42200.0 | nM | 4.38 |