Assay Detail
Binding
CHEMBL711700
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In vitro activation of mouse recombinant Melanocortin-5 receptor.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors. 1. Modifications at the His position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.92 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.15 |
| CHEMBL386583 | — | — | 1 | 9.80 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.36 |
| CHEMBL264190 | — | — | 1 | 8.40 |
| CHEMBL330561 | — | — | 1 | 7.39 |
| CHEMBL405174 | — | — | 1 | 7.34 |
| CHEMBL317968 | — | — | 1 | 7.03 |
| CHEMBL94391 | — | — | 1 | 6.86 |
| CHEMBL327479 | — | — | 1 | 6.84 |
| CHEMBL330233 | — | — | 1 | 6.52 |
| CHEMBL96871 | — | — | 1 | 6.43 |
| CHEMBL431092 | — | — | 1 | 6.42 |
| CHEMBL317969 | — | — | 1 | 6.40 |
| CHEMBL432201 | — | — | 1 | 6.29 |
| CHEMBL94369 | — | — | 1 | 6.22 |
| CHEMBL320157 | — | — | 1 | 6.17 |
| CHEMBL432027 | — | — | 1 | 5.90 |
| CHEMBL329490 | — | — | 1 | 5.65 |
| CHEMBL96531 | — | — | 1 | 5.62 |
| CHEMBL329847 | — | — | 1 | 5.53 |
| CHEMBL275303 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.071 | nM | 10.15 |
| CHEMBL386583 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL264190 | — | EC50 | = | 3.96 | nM | 8.40 |
| CHEMBL330561 | — | EC50 | = | 40.5 | nM | 7.39 |
| CHEMBL405174 | — | EC50 | = | 45.6 | nM | 7.34 |
| CHEMBL317968 | — | EC50 | = | 92.5 | nM | 7.03 |
| CHEMBL94391 | — | EC50 | = | 138.0 | nM | 6.86 |
| CHEMBL327479 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL330233 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL96871 | — | EC50 | = | 369.0 | nM | 6.43 |
| CHEMBL431092 | — | EC50 | = | 381.0 | nM | 6.42 |
| CHEMBL317969 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL432201 | — | EC50 | = | 507.0 | nM | 6.29 |
| CHEMBL94369 | — | EC50 | = | 606.0 | nM | 6.22 |
| CHEMBL320157 | — | EC50 | = | 684.0 | nM | 6.17 |
| CHEMBL432027 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL329490 | — | EC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL96531 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL329847 | — | EC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL275303 | — | EC50 | = | 12000.0 | nM | 4.92 |