Assay Detail
Functional
CHEMBL711701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity towards mouse Melanocortin-5 receptor (mMC5R)
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 6.31 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 10.15 |
| CHEMBL430239 | MELATONAN | — | 1 | 9.80 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 9.36 |
| CHEMBL322610 | — | — | 1 | 8.80 |
| CHEMBL264190 | — | — | 1 | 8.40 |
| CHEMBL319871 | — | — | 1 | 7.94 |
| CHEMBL103817 | — | — | 1 | 7.46 |
| CHEMBL321870 | — | — | 1 | 7.29 |
| CHEMBL50056 | — | — | 1 | 6.99 |
| CHEMBL102688 | — | — | 2 | 6.58 |
| CHEMBL105113 | — | — | 1 | 6.20 |
| CHEMBL430843 | — | — | 1 | 5.55 |
| CHEMBL317228 | — | — | 1 | 5.40 |
| CHEMBL106959 | — | — | 1 | 5.37 |
| CHEMBL421028 | — | — | 1 | 5.26 |
| CHEMBL322889 | — | — | 1 | 5.16 |
| CHEMBL104397 | — | — | 1 | 5.13 |
| CHEMBL430489 | — | — | 1 | 5.01 |
| CHEMBL319922 | — | — | 1 | 4.95 |
| CHEMBL102391 | — | — | 1 | 4.93 |
| CHEMBL431242 | — | — | 1 | 4.74 |
| CHEMBL607104 | — | — | 1 | 4.67 |
| CHEMBL104880 | — | — | 1 | 4.49 |
| CHEMBL104052 | — | — | 1 | 4.44 |
| CHEMBL104010 | — | — | 1 | 4.38 |
| CHEMBL432018 | — | — | 1 | - |
| CHEMBL317210 | — | — | 1 | - |
| CHEMBL607103 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441738 | AFAMELANOTIDE | EC50 | = | 0.071 | nM | 10.15 |
| CHEMBL430239 | MELATONAN | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL214332 | INTERMEDINE | EC50 | = | 0.44 | nM | 9.36 |
| CHEMBL322610 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL264190 | — | EC50 | = | 3.96 | nM | 8.40 |
| CHEMBL319871 | — | EC50 | = | 11.6 | nM | 7.94 |
| CHEMBL103817 | — | EC50 | = | 34.7 | nM | 7.46 |
| CHEMBL321870 | — | EC50 | = | 51.4 | nM | 7.29 |
| CHEMBL50056 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL102688 | — | EC50 | = | 263.0 | nM | 6.58 |
| CHEMBL105113 | — | EC50 | = | 631.0 | nM | 6.20 |
| CHEMBL102688 | — | EC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL430843 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL317228 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL106959 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL421028 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL322889 | — | EC50 | = | 6950.0 | nM | 5.16 |
| CHEMBL104397 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL430489 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL319922 | — | EC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL102391 | — | EC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL431242 | — | EC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL607104 | — | EC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL104880 | — | EC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL104052 | — | EC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL104010 | — | EC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL432018 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL317210 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL607103 | — | EC50 | > | 100000.0 | nM | - |