Assay Detail
Binding
CHEMBL711710
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro binding affinity for displacement of [3H]M-MPEP from membrane of L(-tk) cells expressing the Metabotropic glutamate receptor 5, activity expressed as IC50
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.37 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112677 | — | — | 1 | 8.44 |
| CHEMBL66654 | — | — | 1 | 7.70 |
| CHEMBL88612 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112677 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL66654 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL88612 | — | IC50 | = | 1100.0 | nM | 5.96 |