Assay Detail
Functional
CHEMBL712033
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Inhibitory concentration on parentral (sensitive) L1210 leukemia cells.
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Additional nucleotide derivatives of mitosenes. Synthesis and activity against parental and multidrug resistant L1210 leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.63 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298359 | MITOMYCIN A | 3.0 | 1 | 9.52 |
| CHEMBL448290 | THIOINOSINE | -1.0 | 1 | 8.00 |
| CHEMBL611830 | — | — | 2 | 7.96 |
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | 4.0 | 1 | 7.70 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.44 |
| CHEMBL294385 | — | — | 1 | 7.29 |
| CHEMBL42099 | — | — | 1 | 7.16 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.05 |
| CHEMBL2368668 | — | — | 1 | 6.66 |
| CHEMBL2368664 | — | — | 1 | 6.50 |
| CHEMBL307679 | — | — | 1 | 6.37 |
| CHEMBL611836 | — | — | 1 | 6.26 |
| CHEMBL61803 | — | — | 1 | 6.22 |
| CHEMBL293948 | — | — | 1 | 6.13 |
| CHEMBL2368670 | — | — | 2 | 5.72 |
| CHEMBL60397 | — | — | 1 | 5.62 |
| CHEMBL2368669 | — | — | 1 | 4.61 |
| CHEMBL3350473 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298359 | MITOMYCIN A | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL448290 | THIOINOSINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL611830 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL803 | CYTARABINE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL294385 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL42099 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2368668 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2368664 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL611830 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL307679 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL611836 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL61803 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL293948 | — | IC50 | = | 746.0 | nM | 6.13 |
| CHEMBL2368670 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL60397 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL2368670 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL2368669 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL3350473 | — | IC50 | = | 28100.0 | nM | 4.55 |