Assay Detail
Functional
CHEMBL712104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit growth of human tumor MFC7-R (breast) cell line.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.70 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126916 | — | — | 1 | 8.68 |
| CHEMBL126678 | — | — | 1 | 8.66 |
| CHEMBL420349 | — | — | 1 | 8.55 |
| CHEMBL340628 | — | — | 1 | 8.47 |
| CHEMBL127450 | — | — | 1 | 8.37 |
| CHEMBL339370 | — | — | 1 | 8.31 |
| CHEMBL340250 | — | — | 1 | 8.28 |
| CHEMBL340719 | — | — | 1 | 8.24 |
| CHEMBL339521 | — | — | 1 | 8.19 |
| CHEMBL340030 | — | — | 1 | 8.07 |
| CHEMBL419594 | — | — | 1 | 8.04 |
| CHEMBL339283 | — | — | 1 | 7.98 |
| CHEMBL339531 | — | — | 1 | 7.92 |
| CHEMBL421653 | — | — | 1 | 7.90 |
| CHEMBL125399 | — | — | 1 | 7.76 |
| CHEMBL129126 | — | — | 1 | 7.70 |
| CHEMBL435607 | — | — | 1 | 7.65 |
| CHEMBL340031 | — | — | 1 | 7.52 |
| CHEMBL419616 | — | — | 1 | 7.48 |
| CHEMBL126932 | — | — | 1 | 7.44 |
| CHEMBL338256 | — | — | 1 | 7.32 |
| CHEMBL339519 | — | — | 1 | 7.19 |
| CHEMBL341465 | — | — | 1 | 7.12 |
| CHEMBL340127 | — | — | 1 | 7.06 |
| CHEMBL338714 | — | — | 1 | 6.91 |
| CHEMBL339518 | — | — | 1 | 6.79 |
| CHEMBL338139 | — | — | 1 | 6.67 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.63 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126916 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL126678 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL420349 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL340628 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL127450 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL339370 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL340250 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL340719 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL339521 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL340030 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL419594 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL339283 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL339531 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL421653 | — | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL125399 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL129126 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL435607 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL340031 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL419616 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL126932 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL338256 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL339519 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL341465 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL340127 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL338714 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL339518 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL338139 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 299.0 | nM | 6.52 |