Assay Detail
Functional
CHEMBL712153
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In vitro inhibition of growth of MCF-7 human breast adenocarcinoma using 72 hours continuous exposure
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Breast |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.06 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170101 | — | — | 1 | 7.75 |
| CHEMBL30842 | — | — | 1 | 7.64 |
| CHEMBL31176 | — | — | 1 | 7.48 |
| CHEMBL13659 | — | — | 1 | 7.43 |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | — | 1 | 7.21 |
| CHEMBL285232 | — | — | 1 | 7.20 |
| CHEMBL31609 | — | — | 1 | 7.07 |
| CHEMBL417304 | — | — | 1 | 6.94 |
| CHEMBL30301 | — | — | 1 | 6.60 |
| CHEMBL29713 | — | — | 1 | 5.30 |
| CHEMBL31107 | — | — | 1 | - |
| CHEMBL31027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170101 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL30842 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL31176 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL13659 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL285232 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL31609 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL417304 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL30301 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL29713 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL31107 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL31027 | — | IC50 | > | 50000.0 | nM | - |