Assay Detail
Binding
CHEMBL712305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human microsomal triglyceride transfer protein using triglyceride transfer assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Microsomal triglyceride transfer protein large subunit (CHEMBL2569) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354541 | LOMITAPIDE | 4.0 | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354541 | LOMITAPIDE | IC50 | = | 8.0 | nM | 8.10 |