Assay Detail
Functional
CHEMBL712311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on reversal of [3H]- VBL accumulation in MDA-435/LCC6 (Pgp-negative) cells.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.56 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.22 |
| CHEMBL419965 | — | — | 1 | 6.16 |
| CHEMBL131172 | — | — | 1 | 6.05 |
| CHEMBL338904 | — | — | 1 | 5.82 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.51 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 4.68 |
| CHEMBL129251 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL419965 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL131172 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL338904 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL103 | PROGESTERONE | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL129251 | — | EC50 | = | 33400.0 | nM | 4.48 |