Assay Detail
Functional
CHEMBL712344
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MT4 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 8.18 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2372985 | — | — | 1 | 9.40 |
| CHEMBL2372997 | — | — | 1 | 9.30 |
| CHEMBL2372993 | — | — | 1 | 9.22 |
| CHEMBL2373004 | — | — | 1 | 8.92 |
| CHEMBL2372989 | — | — | 1 | 8.57 |
| CHEMBL2373002 | — | — | 1 | 8.55 |
| CHEMBL2372983 | — | — | 1 | 8.48 |
| CHEMBL2372994 | — | — | 1 | 8.40 |
| CHEMBL2373001 | — | — | 1 | 8.34 |
| CHEMBL2372999 | — | — | 1 | 8.18 |
| CHEMBL2372995 | — | — | 1 | 8.17 |
| CHEMBL2372990 | — | — | 1 | 8.11 |
| CHEMBL2372996 | — | — | 1 | 8.05 |
| CHEMBL2373005 | — | — | 1 | 7.44 |
| CHEMBL2373000 | — | — | 1 | 7.43 |
| CHEMBL2373003 | — | — | 1 | 7.40 |
| CHEMBL2372986 | — | — | 1 | 7.17 |
| CHEMBL2372998 | — | — | 1 | 7.14 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2372985 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2372997 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2372993 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2373004 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2372989 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL2373002 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2372983 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2372994 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2373001 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL2372999 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL2372995 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2372990 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL2372996 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL2373005 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2373000 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2373003 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2372986 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL2372998 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 88.0 | nM | 7.06 |