Assay Detail
Functional
CHEMBL712534
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Inhibitory activity against Leishmania donovani (macrophage)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.06 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48856 | — | — | 1 | 6.89 |
| CHEMBL304666 | — | — | 1 | 6.82 |
| CHEMBL62575 | — | — | 1 | 6.80 |
| CHEMBL49128 | — | — | 1 | 6.32 |
| CHEMBL416108 | — | — | 1 | 6.22 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.00 |
| CHEMBL52210 | — | — | 1 | 5.84 |
| CHEMBL63034 | — | — | 1 | 5.44 |
| CHEMBL46010 | — | — | 1 | 5.28 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.03 |
| CHEMBL62528 | — | — | 1 | - |
| CHEMBL48621 | — | — | 1 | - |
| CHEMBL292081 | — | — | 1 | - |
| CHEMBL291613 | — | — | 1 | - |
| CHEMBL298369 | — | — | 1 | - |
| CHEMBL65001 | — | — | 1 | - |
| CHEMBL45843 | — | — | 1 | - |
| CHEMBL63819 | — | — | 1 | - |
| CHEMBL49627 | — | — | 1 | - |
| CHEMBL50440 | — | — | 1 | - |
| CHEMBL413331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48856 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL304666 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL62575 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL49128 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL416108 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL52210 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL63034 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL46010 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL62528 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL48621 | — | IC50 | > | 8000.0 | nM | - |
| CHEMBL292081 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL291613 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL298369 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL65001 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL45843 | — | IC50 | > | 6800.0 | nM | - |
| CHEMBL63819 | — | IC50 | > | 29000.0 | nM | - |
| CHEMBL49627 | — | IC50 | > | 5600.0 | nM | - |
| CHEMBL50440 | — | IC50 | > | 24000.0 | nM | - |
| CHEMBL413331 | — | IC50 | > | 6300.0 | nM | - |